Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Memantine is dosed at 0.3–1 mg/kg PO q12h in dogs, per Schneider, B.M., Dodman, N.H., and Maranda, L. (2009b). Use of memantine in treatment of canine compulsive disorders. Journal of Veterinary Behavior: Clinical Applications and Research 4 (3): 118-126. — Verified against Veterinary Psychopharmacology (Crowell-Davis), 2nd Ed, p.206 (2026-08-01).. Memantine is used in dogs for Cognitive dysfunction syndrome (investigational). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Memantine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Namenda
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.3–1 mg/kg | q12h | Long-term | Cognitive dysfunction syndrome (investigational) | Weak | Schneider, B.M., Dodman, N.H., and Maranda, L. (2009b). Use of memantine in treatment of canine compulsive disorders. Journal of Veterinary Behavior: Clinical Applications and Research 4 (3): 118-126. — Verified against Veterinary Psychopharmacology (Crowell-Davis), 2nd Ed, p.206 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Non-competitive NMDA glutamate receptor antagonist. Blocks pathological sustained NMDA activation while allowing normal synaptic transmission.
Limited veterinary data. Investigated for cognitive dysfunction syndrome in dogs. May cause restlessness, GI upset. Renal elimination — adjust in renal disease.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Memantine dose range in dogs, with cited source references: PO 0.3–1 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Memantine in dogs: PO.
Cited course lengths for Memantine in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Memantine is indicated in dogs for: Cognitive dysfunction syndrome (investigational).
These are general warnings for Memantine across species; consult the dog dosing table above for species-specific guidance. Limited veterinary data. Investigated for cognitive dysfunction syndrome in dogs. May cause restlessness, GI upset. Renal elimination — adjust in renal disease.
Why a species-specific page? Memantine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.