Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Donepezil is dosed at 0.5–1 mg/kg PO q24h in dogs, per Landsberg GM, JAVMA 2008; Canine cognitive dysfunction review. Donepezil is used in dogs for Canine cognitive dysfunction. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Donepezil in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Aricept
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q24h | Long-term use; reassess every 3-6 months | Canine cognitive dysfunction | Weak | Landsberg GM, JAVMA 2008; Canine cognitive dysfunction review |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reversible, non-competitive acetylcholinesterase inhibitor that increases acetylcholine concentrations at cholinergic synapses, improving cognitive function.
May cause GI upset, bradycardia, and muscle fasciculations. Monitor heart rate. Limited veterinary data — used investigationally for canine cognitive dysfunction.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Donepezil dose range in dogs, with cited source references: PO 0.5–1 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Donepezil in dogs: PO.
Cited course lengths for Donepezil in dogs include: Long-term use; reassess every 3-6 months. Duration depends on the indication — match it to the specific dose rule in the table above.
Donepezil is indicated in dogs for: Canine cognitive dysfunction.
These are general warnings for Donepezil across species; consult the dog dosing table above for species-specific guidance. May cause GI upset, bradycardia, and muscle fasciculations. Monitor heart rate. Limited veterinary data — used investigationally for canine cognitive dysfunction.
Why a species-specific page? Donepezil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.