ExoticRx · exoticrx.com/drugs/miconazole-polymyxin-b-prednisolone-otic
US brand names:Surolan
Triple combination: miconazole disrupts fungal cell membranes; polymyxin B disrupts gram-negative bacterial membranes; prednisolone reduces inflammation and pruritus.
Effective against Malassezia and mixed infections. Do not use with ruptured tympanic membrane. Shake well before use. Usually 5-7 days treatment.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Otic | Surolan | 5-10 drops per ear q12h | Strong | Mueller RS, Bergvall K, Bensignor E et al. (2012) A review of topical therapy for skin infections with bacteria and yeast. Veterinary Dermatology 23, 330-341 doi:10.1111/j.1365-3164.2012.01057.x — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.281 (2026-08-01). |
| Cat (Domestic) | Otic | Lower volume for cats | 3-5 drops per ear q12h | Moderate | Mueller RS, Bergvall K, Bensignor E et al. (2012) A review of topical therapy for skin infections with bacteria and yeast. Veterinary Dermatology 23, 330-341 doi:10.1111/j.1365-3164.2012.01057.x — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.281 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.