ExoticRx · exoticrx.com/drugs/milbemycin-oxime
US brand names:Interceptor, Sentinel(combination)
Milbemycin Oxime is dosed at 0.5–1 mg/kg PO q30d in dogs, per (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01).. Verify against current literature before clinical use.
Binds glutamate-gated chloride channels, causing paralysis of susceptible nematodes and arthropods.
Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q30d | Strong | (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). |
| Cat (Domestic) | PO | 2 mg/kg | q30d | Strong | (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.