Cat · Felis catus · typical adult weight 2.50–7.00 kg
Milbemycin Oxime is dosed at 2 mg/kg PO q30d in cats, per (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). — Plumb's 10th ed (held) printed p.886, Milbemycin Oxime monograph spanning p.885-886; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Milbemycin Oxime is used in cats for Heartworm prevention. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Milbemycin Oxime in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Interceptor, Sentinel
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2 mg/kg | q30d | Year-round monthly | Heartworm prevention | Strong | (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). — Plumb's 10th ed (held) printed p.886, Milbemycin Oxime monograph spanning p.885-886; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.560 | • Heartworm and endoparasite control: 2 mg/kg q30days PO. |
| 1–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.560 | • Demodicosis in cats: 1-2 mg/kg q24h, PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Binds glutamate-gated chloride channels, causing paralysis of susceptible nematodes and arthropods.
Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Milbemycin Oxime dose range in cats, with cited source references: PO 2 mg/kg q30d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Milbemycin Oxime in cats: PO.
Cited course lengths for Milbemycin Oxime in cats include: Year-round monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Milbemycin Oxime is indicated in cats for: Heartworm prevention.
These are general warnings for Milbemycin Oxime across species; consult the cat dosing table above for species-specific guidance. Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Why a species-specific page? Milbemycin Oxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.