Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Milbemycin Oxime is dosed at 0.5–1 mg/kg PO q30d in dogs, per (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). — Plumb's 10th ed (held) printed p.885, Milbemycin Oxime monograph spanning p.885-886; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Milbemycin Oxime is used in dogs for Heartworm prevention, intestinal parasites. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Milbemycin Oxime in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Interceptor, Sentinel
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q30d | Year-round monthly | Heartworm prevention, intestinal parasites | Strong | (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). — Plumb's 10th ed (held) printed p.885, Milbemycin Oxime monograph spanning p.885-886; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.560 | • Heartworm prevention and control of endoparasites: 0.5 mg/kg q30days PO. |
| 2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.560 | • Demodicosis: 2 mg/kg q24h PO for 60-120 days or 1 mg/kg daily until a clini- |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.560 | • Demodicosis: 2 mg/kg q24h PO for 60-120 days or 1 mg/kg daily until a clini- |
| 3 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.560 | cal cure is observed, followed by 3 mg/kg once per week until a parasitological |
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Binds glutamate-gated chloride channels, causing paralysis of susceptible nematodes and arthropods.
Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Milbemycin Oxime dose range in dogs, with cited source references: PO 0.5–1 mg/kg q30d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Milbemycin Oxime in dogs: PO.
Cited course lengths for Milbemycin Oxime in dogs include: Year-round monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Milbemycin Oxime is indicated in dogs for: Heartworm prevention, intestinal parasites.
These are general warnings for Milbemycin Oxime across species; consult the dog dosing table above for species-specific guidance. Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Why a species-specific page? Milbemycin Oxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.