Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Milbemycin Oxime is dosed at 0.5–1 mg/kg PO q30d in dogs, per (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01).. Milbemycin Oxime is used in dogs for Heartworm prevention, intestinal parasites. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Milbemycin Oxime in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Interceptor, Sentinel
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q30d | Year-round monthly | Heartworm prevention, intestinal parasites | Strong | (Label information; Interceptor®) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.913 (2026-08-01). |
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Binds glutamate-gated chloride channels, causing paralysis of susceptible nematodes and arthropods.
Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Milbemycin Oxime dose range in dogs, with cited source references: PO 0.5–1 mg/kg q30d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Milbemycin Oxime in dogs: PO.
Cited course lengths for Milbemycin Oxime in dogs include: Year-round monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Milbemycin Oxime is indicated in dogs for: Heartworm prevention, intestinal parasites.
These are general warnings for Milbemycin Oxime across species; consult the dog dosing table above for species-specific guidance. Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.
Why a species-specific page? Milbemycin Oxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.