ExoticRx · exoticrx.com/drugs/mitotane
US brand names:Lysodren
Mitotane is dosed at 25–50 mg/kg PO q24h (induction), then q7d (maintenance) in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Selectively destroys the zona fasciculata and zona reticularis of the adrenal cortex, reducing cortisol production. Also alters extra-adrenal steroid metabolism.
TOXIC — requires careful dose titration and ACTH stimulation test monitoring. Iatrogenic Addison's crisis is a serious risk. Handler precautions (carcinogenic). Give with food (fat enhances absorption). Dogs only.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 25–50 mg/kg | q24h (induction), then q7d (maintenance) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.