ExoticRx · exoticrx.com/drugs/mitotane
Lysodren
Selectively destroys the zona fasciculata and zona reticularis of the adrenal cortex, reducing cortisol production. Also alters extra-adrenal steroid metabolism.
TOXIC — requires careful dose titration and ACTH stimulation test monitoring. Iatrogenic Addison's crisis is a serious risk. Handler precautions (carcinogenic). Give with food (fat enhances absorption). Dogs only.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 25–50 mg/kg | q24h (induction), then q7d (maintenance) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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