Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mitotane is dosed at 25–50 mg/kg PO q24h (induction), then q7d (maintenance) in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.899, Mitotane monograph spanning p.899-901; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Mitotane is used in dogs for Pituitary-dependent hyperadrenocorticism. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mitotane in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lysodren
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25–50 mg/kg | q24h (induction), then q7d (maintenance) | Induction: 7-14 days; Maintenance: lifelong | Pituitary-dependent hyperadrenocorticism | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.899, Mitotane monograph spanning p.899-901; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 30–50 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.288 | 30-50 mg/kg p.o. (with/after food) q24h to effect (generally 3-10 days) then 50 mg/kg p.o. q7-1 |
| 50 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.288 | after food) q24h to effect (generally 3-10 days) then 50 mg/kg p.o. q7-14 days in 2-3 divided doses as required. Higher doses (50-150 mg/kg p.o. q24h) m |
| 50–150 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.288 | q7-14 days in 2-3 divided doses as required. Higher doses (50-150 mg/kg p.o. q24h) may become necessary for adrenal carcinomas |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively destroys the zona fasciculata and zona reticularis of the adrenal cortex, reducing cortisol production. Also alters extra-adrenal steroid metabolism.
TOXIC — requires careful dose titration and ACTH stimulation test monitoring. Iatrogenic Addison's crisis is a serious risk. Handler precautions (carcinogenic). Give with food (fat enhances absorption). Dogs only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mitotane dose range in dogs, with cited source references: PO 25–50 mg/kg q24h (induction), then q7d (maintenance). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mitotane in dogs: PO.
Cited course lengths for Mitotane in dogs include: Induction: 7-14 days; Maintenance: lifelong. Duration depends on the indication — match it to the specific dose rule in the table above.
Mitotane is indicated in dogs for: Pituitary-dependent hyperadrenocorticism.
These are general warnings for Mitotane across species; consult the dog dosing table above for species-specific guidance. TOXIC — requires careful dose titration and ACTH stimulation test monitoring. Iatrogenic Addison's crisis is a serious risk. Handler precautions (carcinogenic). Give with food (fat enhances absorption). Dogs only.
Why a species-specific page? Mitotane pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 50 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.567 | • PDH: 50 mg/kg/day (in divided doses) PO for 5-14 days, then 50-70 mg/kg/ |
| 50–70 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.567 | • PDH: 50 mg/kg/day (in divided doses) PO for 5-14 days, then 50-70 mg/kg/ |
| 50–75 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.567 | • Adrenal tumor: 50-75 mg/kg/day for 10 days, then 75-100 mg/kg/week PO. |
| 75–100 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.567 | • Adrenal tumor: 50-75 mg/kg/day for 10 days, then 75-100 mg/kg/week PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.