Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mitotane is dosed at 25–50 mg/kg PO q24h (induction), then q7d (maintenance) in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Mitotane is used in dogs for Pituitary-dependent hyperadrenocorticism. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mitotane in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lysodren
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25–50 mg/kg | q24h (induction), then q7d (maintenance) | Induction: 7-14 days; Maintenance: lifelong | Pituitary-dependent hyperadrenocorticism | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively destroys the zona fasciculata and zona reticularis of the adrenal cortex, reducing cortisol production. Also alters extra-adrenal steroid metabolism.
TOXIC — requires careful dose titration and ACTH stimulation test monitoring. Iatrogenic Addison's crisis is a serious risk. Handler precautions (carcinogenic). Give with food (fat enhances absorption). Dogs only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mitotane dose range in dogs, with cited source references: PO 25–50 mg/kg q24h (induction), then q7d (maintenance). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mitotane in dogs: PO.
Cited course lengths for Mitotane in dogs include: Induction: 7-14 days; Maintenance: lifelong. Duration depends on the indication — match it to the specific dose rule in the table above.
Mitotane is indicated in dogs for: Pituitary-dependent hyperadrenocorticism.
These are general warnings for Mitotane across species; consult the dog dosing table above for species-specific guidance. TOXIC — requires careful dose titration and ACTH stimulation test monitoring. Iatrogenic Addison's crisis is a serious risk. Handler precautions (carcinogenic). Give with food (fat enhances absorption). Dogs only.
Why a species-specific page? Mitotane pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.