ExoticRx · exoticrx.com/drugs/naltrexone
US brand names:Trexonil, ReVia
Naltrexone is dosed at 1.5 mg/kg PO q8-12h in african grey parrots, per 952. van Zeeland Y. Medication for behavior modification in birds. Vet Clin North Am Exot Anim Pract. 2018;21(1):115-149. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.473 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.10 (Psychotropic and Antiepileptic Agents Used in Birds.a,b). Verify against current literature before clinical use.
Long-acting competitive opioid receptor antagonist. Oral bioavailability and longer half-life than naloxone.
Used for stereotypic/compulsive behaviors (self-mutilation, cribbing in horses). Hepatotoxicity at high doses. Blocks endogenous opioid reward pathways.
Species references:All African Grey Parrot drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 mg/kg | q12h | Weak | Plumb's 10th ed printed p.926, Naltrexone monograph spanning p.926-927.Compilation only — we have not located an independent source that prints this figure. |
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