ExoticRx · exoticrx.com/drugs/naltrexone
US brand names:Trexonil, ReVia
Naltrexone is dosed at 1–2 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.954 (2026-08-01).. Verify against current literature before clinical use.
Long-acting competitive opioid receptor antagonist. Oral bioavailability and longer half-life than naloxone.
Used for stereotypic/compulsive behaviors (self-mutilation, cribbing in horses). Hepatotoxicity at high doses. Blocks endogenous opioid reward pathways.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 mg/kg | q12h | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.954 (2026-08-01). |
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