Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Naltrexone is dosed at 1–2 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.954 (2026-08-01).. Naltrexone is used in dogs for Stereotypic/compulsive behaviors. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Naltrexone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Trexonil, ReVia
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Variable | Stereotypic/compulsive behaviors | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.954 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Long-acting competitive opioid receptor antagonist. Oral bioavailability and longer half-life than naloxone.
Used for stereotypic/compulsive behaviors (self-mutilation, cribbing in horses). Hepatotoxicity at high doses. Blocks endogenous opioid reward pathways.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Naltrexone dose range in dogs, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Naltrexone in dogs: PO.
Cited course lengths for Naltrexone in dogs include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Naltrexone is indicated in dogs for: Stereotypic/compulsive behaviors.
These are general warnings for Naltrexone across species; consult the dog dosing table above for species-specific guidance. Used for stereotypic/compulsive behaviors (self-mutilation, cribbing in horses). Hepatotoxicity at high doses. Blocks endogenous opioid reward pathways.
Why a species-specific page? Naltrexone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.