Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Naltrexone is dosed at 1–2 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.954 (2026-08-01). — Plumb's 10th ed (held) printed p.926, Naltrexone monograph spanning p.926-927; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Naltrexone is used in dogs for Stereotypic/compulsive behaviors. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Naltrexone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Trexonil, ReVia
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Variable | Stereotypic/compulsive behaviors | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.954 (2026-08-01). — Plumb's 10th ed (held) printed p.926, Naltrexone monograph spanning p.926-927; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.582 | • For behavior problems: 2.2 mg/kg q12h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Long-acting competitive opioid receptor antagonist. Oral bioavailability and longer half-life than naloxone.
Used for stereotypic/compulsive behaviors (self-mutilation, cribbing in horses). Hepatotoxicity at high doses. Blocks endogenous opioid reward pathways.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Naltrexone dose range in dogs, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Naltrexone in dogs: PO.
Cited course lengths for Naltrexone in dogs include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Naltrexone is indicated in dogs for: Stereotypic/compulsive behaviors.
These are general warnings for Naltrexone across species; consult the dog dosing table above for species-specific guidance. Used for stereotypic/compulsive behaviors (self-mutilation, cribbing in horses). Hepatotoxicity at high doses. Blocks endogenous opioid reward pathways.
Why a species-specific page? Naltrexone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.