ExoticRx · exoticrx.com/drugs/neo-poly-bac-ophthalmic
US brand names:Neo-Poly-Bac, AK-Spore
Triple antibiotic: neomycin (30S ribosomal), polymyxin B (membrane disruption), bacitracin (cell wall synthesis). Broad gram-positive and gram-negative coverage.
Workhorse ophthalmic antibiotic combination. Safe with corneal ulcers (ointment provides lubrication). Neomycin hypersensitivity possible. No Pseudomonas coverage (bacitracin formulation).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | Ophthalmic | Same as dogs | q6-8h | Strong | Hume-Smith KM, Groth AD, Rishniw M, Walter-Grimm LA, Plunkett SJ, Maggs DJ. Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation: 61 cats (1993-2010). J Feline Med Surg. 2011;13(10):744-751. doi:10.1016/j.jfms.2011.06.007 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1436 (2026-08-01). |
| Dog (Domestic) | Ophthalmic | Triple antibiotic ointment/solution | q6-8h | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1436 (2026-08-01). |
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