ExoticRx · exoticrx.com/drugs/neo-poly-bac-ophthalmic
US brand names:Neo-Poly-Bac, AK-Spore
Triple antibiotic: neomycin (30S ribosomal), polymyxin B (membrane disruption), bacitracin (cell wall synthesis). Broad gram-positive and gram-negative coverage.
Workhorse ophthalmic antibiotic combination. Safe with corneal ulcers (ointment provides lubrication). Neomycin hypersensitivity possible. No Pseudomonas coverage (bacitracin formulation).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | Ophthalmic | See the cited source for the printed regimen | q6-8h | Strong | Hume-Smith KM, Groth AD, Rishniw M, Walter-Grimm LA, Plunkett SJ, Maggs DJ. Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation: 61 cats (1993-2010). J Feline Med Surg. 2011;13(10):744-751. doi:10.1016/j.jfms.2011.06.007 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1436 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.1436' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1409; verified by finding the drug named there. If you are holding the book, turn to p.1409. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | Ophthalmic | See the cited source for the printed regimen | q6-8h |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1436 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.1436' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1409; verified by finding the drug named there. If you are holding the book, turn to p.1409. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |