ExoticRx · exoticrx.com/drugs/neomycin-polymyxin-hydrocortisone-otic
US brand names:Cortisporin Otic
Neomycin inhibits bacterial protein synthesis. Polymyxin B disrupts gram-negative cell membranes. Hydrocortisone reduces inflammation and pruritus.
Neomycin is ototoxic — do NOT use if tympanic membrane is ruptured. Contact sensitization to neomycin common with prolonged use. Suspension preferred over solution.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | Otic | Verify intact tympanic membrane before use | 3-5 drops affected ear q12h | Strong | Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.298 (2026-08-01). |
| Dog (Domestic) | Otic | Classic veterinary otic combination | 5-10 drops affected ear q12h | Strong | Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.298 (2026-08-01). |
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