ExoticRx · exoticrx.com/drugs/pasireotide
US brand names:Signifor
Pasireotide is dosed at 0.03–0.1 mg/kg SC q12h or monthly (LAR) in cats, per Corroborated 2026-07-31: Scudder CJ et al. J Vet Intern Med 2015;29(4):1074-1080. doi:10.1111/jvim.12608 PMID:25945588 - cat, hypersomatotropism, pasireotide 0.03 mg/kg SC q12h (3-day study); monthly LAR 6-8 mg/kg SC (Gostelow R et al. J Vet Intern Med 2017;31(2):355-364. doi:10.1111/jvim.14662 PMID:28145031).. Verify against current literature before clinical use.
Somatostatin analogue with broad somatostatin receptor affinity (SST1,2,3,5) that suppresses ACTH secretion from corticotroph adenomas.
Hyperglycemia is very common. Monitor blood glucose. Investigational for pituitary-dependent hyperadrenocorticism in dogs.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | SC | 0.03–0.1 mg/kg | q12h or monthly (LAR) | Weak | Corroborated 2026-07-31: Scudder CJ et al. J Vet Intern Med 2015;29(4):1074-1080. doi:10.1111/jvim.12608 PMID:25945588 - cat, hypersomatotropism, pasireotide 0.03 mg/kg SC q12h (3-day study); monthly LAR 6-8 mg/kg SC (Gostelow R et al. J Vet Intern Med 2017;31(2):355-364. doi:10.1111/jvim.14662 PMID:28145031). |
| Dog (Domestic) | SC | 0.03–0.1 mg/kg | q12h (SC) or monthly (LAR) |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Corroborated 2026-07-31: Lottati M, Bruyette DS. J Am Vet Med Assoc 2018;252(11):1403-1408. doi:10.2460/javma.252.11.1403 PMID:29772978 - dog, pituitary-dependent hyperadrenocorticism with macroadenoma, pasireotide 0.03 mg/kg SC q12h for 6 mo added to trilostane or mitotane. |