What is Penicillin G procaine used for?

Penicillin G procaine is indicated for: Bacterial infection.

Which species have cited Penicillin G procaine dosing data?

Penicillin G procaine dosing in the ExoticRx formulary covers 1 species: African Pygmy Hedgehog.

Is Penicillin G procaine a controlled substance?

Penicillin G procaine is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Penicillin G procaine

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Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu

Rabbit: Oral beta-lactams cause fatal dysbiosis in rabbitsOral amoxicillin (and other oral beta-lactams) selectively destroy gram-positive hindgut flora in rabbits, allowing Clostridium spiroforme overgrowth and fatal enterotoxemia. Never administer oral beta-lactams to rabbits. Parenteral administration carries a lower risk than the oral route, but is not established as safe in rabbits.
Guinea Pig: Oral beta-lactams cause fatal dysbiosis in guinea pigsOral amoxicillin reliably causes Clostridium difficile-mediated fatal enterotoxemia in guinea pigs. Same mechanism as in rabbits. Parenteral administration carries a lower risk than the oral route; parenteral ceftiofur specifically has been given to guinea pigs and chinchillas without adverse effect.
Chinchilla: Oral beta-lactams cause fatal dysbiosis in chinchillasChinchillas are hindgut fermenters with the same flora dependence as rabbits and guinea pigs. Oral penicillins and oral cephalosporins trigger Clostridium overgrowth and fatal enterotoxemia. Never give oral beta-lactams; parenteral routes and trimethoprim-sulfa, fluoroquinolones, or chloramphenicol are the safer choices.
Oral beta-lactams cause fatal enterocolitis in hamsters

Degu: Oral beta-lactams risk fatal dysbiosis in degusDegus are caviomorph hindgut fermenters closely related to chinchillas and guinea pigs. Degu-specific data is limited, so this warning is extrapolated from those related hystricomorphs — but the shared physiology makes oral beta-lactam enterotoxemia the expected outcome. Treat as contraindicated; use the safer alternatives.

Penicillin G procaine is dosed at 40000 IU/kg SC, IM q24h in african pygmy hedgehogs, per 29. Isenbügel E, Baumgartner R. Diseases of the hedgehog. In: Fowler M, eds. Zoo and Wild Animal Medicine: Current Therapy, 3rd ed., WB Saunders, Philadelphia, PA; 1993:294-302. | 52. Morrisey JK, Carpenter JW, et al. Formulary. In: Quesenberry Q, Orcutt C, Mans C, et al. Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.734 — Carpenter 6th ed, Table 8.1 (Antimicrobial Agents Used in Hedgehogs), row "Penicillin G procaine 40,000 IU/kg SC, IM q24h29,52". Unit on the page is IU/kg, not mg/kg. Verify against current literature before clinical use.

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· 29. Isenbügel E, Baumgartner R. Diseases of the hedgehog. In: Fowler M, eds. Zoo and Wild Animal Medicine: Current Therapy, 3rd ed., WB Saunders, Philadelphia, PA; 1993:294-302. | 52. Morrisey JK, Carpenter JW, et al. Formulary. In: Quesenberry Q, Orcutt C, Mans C, et al. Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.734 — Carpenter 6th ed, Table 8.1 (Antimicrobial Agents Used in Hedgehogs), row "Penicillin G procaine 40,000 IU/kg SC, IM q24h29,52". Unit on the page is IU/kg, not mg/kg.

Penicillin G procaine

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Species with Penicillin G procaine dosing data (1 dose rule)

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Penicillin G procaine

Drug Class

Routes

Indications

Species with Penicillin G procaine dosing data (1 dose rule)

Evidence levels across 1 dose rule

Upgrade for Full Details

Other formulations of Penicillin

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