ExoticRx · exoticrx.com/drugs/phenylpiperazine-derivatives-trazodone-extended-release
US brand names:Compounded ER Trazodone
Phenylpiperazine Derivatives (Trazodone Extended-Release) is dosed at 3–10 mg/kg PO q12-24h in dogs, per Gruen ME, Sherman BL. Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995-2007). Javma-Journal of the American Veterinary Medical Association. 2008;233:1902-1907. doi:10.2460/javma.233.12.1902 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1295 (2026-08-01).. Verify against current literature before clinical use.
Serotonin antagonist and reuptake inhibitor (SARI). Blocks 5-HT2A receptors and inhibits serotonin reuptake. Extended-release formulation provides longer anxiolysis.
Compounded ER formulation — do not crush. Sedation is primary effect. Serotonin syndrome risk with SSRIs. Priapism reported rarely. Dose to effect.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 3–10 mg/kg | q12-24h | Moderate | Gruen ME, Sherman BL. Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995-2007). Javma-Journal of the American Veterinary Medical Association. 2008;233:1902-1907. doi:10.2460/javma.233.12.1902 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1295 (2026-08-01). |
| Cat (Domestic) | PO | 2–5 mg/kg | q12-24h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.