ExoticRx · exoticrx.com/drugs/phenylpiperazine-derivatives-trazodone-extended-release
US brand names:Compounded ER Trazodone
Phenylpiperazine Derivatives (Trazodone Extended-Release) is dosed at 3–10 mg/kg PO q12-24h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (held), Trazodone monograph, printed p.1268-1269 (corpus PDF p.1295-1296). [LOCATOR CORRECTED - the cited p.1295 was a corpus PDF index.] NOTE - the Dosage Forms section lists ONLY immediate-release trazodone oral tablets and NO veterinary product. No extended-release form appears anywhere in the monograph, so the ER designation and the ER claims in notes are UNSOURCED.. Verify against current literature before clinical use.
Serotonin antagonist and reuptake inhibitor (SARI). Blocks 5-HT2A receptors and inhibits serotonin reuptake. Extended-release formulation provides longer anxiolysis.
Compounded ER formulation — do not crush. Sedation is primary effect. Serotonin syndrome risk with SSRIs. Priapism reported rarely. Dose to effect.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 3–10 mg/kg | q12-24h | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (held), Trazodone monograph, printed p.1268-1269 (corpus PDF p.1295-1296). [LOCATOR CORRECTED - the cited p.1295 was a corpus PDF index.] NOTE - the Dosage Forms section lists ONLY immediate-release trazodone oral tablets and NO veterinary product. No extended-release form appears anywhere in the monograph, so the ER designation and the ER claims in notes are UNSOURCED. |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.