Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Phenylpiperazine Derivatives (Trazodone Extended-Release) is dosed at 3–10 mg/kg PO q12-24h in dogs, per Gruen ME, Sherman BL. Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995-2007). Javma-Journal of the American Veterinary Medical Association. 2008;233:1902-1907. doi:10.2460/javma.233.12.1902 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1295 (2026-08-01).. Phenylpiperazine Derivatives (Trazodone Extended-Release) is used in dogs for Anxiety, post-surgical confinement. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Phenylpiperazine Derivatives (Trazodone Extended-Release) in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Compounded ER Trazodone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 3–10 mg/kg | q12-24h | Short or long-term as needed | Anxiety, post-surgical confinement |
| Gruen ME, Sherman BL. Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995-2007). Javma-Journal of the American Veterinary Medical Association. 2008;233:1902-1907. doi:10.2460/javma.233.12.1902 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1295 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Serotonin antagonist and reuptake inhibitor (SARI). Blocks 5-HT2A receptors and inhibits serotonin reuptake. Extended-release formulation provides longer anxiolysis.
Compounded ER formulation — do not crush. Sedation is primary effect. Serotonin syndrome risk with SSRIs. Priapism reported rarely. Dose to effect.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Phenylpiperazine Derivatives (Trazodone Extended-Release) dose range in dogs, with cited source references: PO 3–10 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Phenylpiperazine Derivatives (Trazodone Extended-Release) in dogs: PO.
Cited course lengths for Phenylpiperazine Derivatives (Trazodone Extended-Release) in dogs include: Short or long-term as needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Phenylpiperazine Derivatives (Trazodone Extended-Release) is indicated in dogs for: Anxiety, post-surgical confinement.
These are general warnings for Phenylpiperazine Derivatives (Trazodone Extended-Release) across species; consult the dog dosing table above for species-specific guidance. Compounded ER formulation — do not crush. Sedation is primary effect. Serotonin syndrome risk with SSRIs. Priapism reported rarely. Dose to effect.
Why a species-specific page? Phenylpiperazine Derivatives (Trazodone Extended-Release) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.