Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Romifidine is dosed at 0.001–0.04 mg/kg IV Single dose in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1129, Romifidine monograph spanning p.1129-1130; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Romifidine monograph, printed p.1129-1130; the earlier note claiming no held source contained this figure was wrong and has been removed. — figure located 2026-08-05 at Plumb's 10th ed printed p.1130, Romifidine monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Romifidine is used in dogs for Sedation (off-label). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Romifidine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sedivet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.001–0.04 mg/kg | Single dose | 30-60 min sedation | Sedation (off-label) | Extrapolated | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1129, Romifidine monograph spanning p.1129-1130; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Romifidine monograph, printed p.1129-1130; the earlier note claiming no held source contained this figure was wrong and has been removed. — figure located 2026-08-05 at Plumb's 10th ed printed p.1130, Romifidine monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Alpha-2 adrenergic agonist causing sedation, analgesia, and muscle relaxation. Less ataxia than xylazine and detomidine. Primarily equine use.
Primarily equine. Bradycardia, initial hypertension then hypotension. Reversible with atipamezole. Second-degree AV block common.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Romifidine dose range in dogs, with cited source references: IV 0.001–0.04 mg/kg Single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Romifidine in dogs: IV.
Cited course lengths for Romifidine in dogs include: 30-60 min sedation. Duration depends on the indication — match it to the specific dose rule in the table above.
Romifidine is indicated in dogs for: Sedation (off-label).
These are general warnings for Romifidine across species; consult the dog dosing table above for species-specific guidance. Primarily equine. Bradycardia, initial hypertension then hypotension. Reversible with atipamezole. Second-degree AV block common.
Why a species-specific page? Romifidine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.