Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Xylazine is dosed at 0.5–1 mg/kg IM Single dose in dogs, per Hartsfield S. Preanesthetic drugs in small animal anesthesia. Presented at: ACVC; 2007. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1348 (2026-08-01).. Xylazine is used in dogs for Sedation, pre-anesthetic. Routes documented in dogs: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Xylazine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rompun, AnaSed
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 0.5–1 mg/kg | Single dose | 20-40 min sedation | Sedation, pre-anesthetic | Strong | Hartsfield S. Preanesthetic drugs in small animal anesthesia. Presented at: ACVC; 2007. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1348 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Xylazine dose range in dogs, with cited source references: IM 0.5–1 mg/kg Single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Xylazine in dogs: IM.
Cited course lengths for Xylazine in dogs include: 20-40 min sedation. Duration depends on the indication — match it to the specific dose rule in the table above.
Xylazine is indicated in dogs for: Sedation, pre-anesthetic.
These are general warnings for Xylazine across species; consult the dog dosing table above for species-specific guidance. Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.