ExoticRx · exoticrx.com/drugs/primidone
US brand names:Mysoline, Neurosyn
Primidone is dosed at 10–25 mg/kg PO q8-12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Metabolized to phenobarbital (major active metabolite) and phenylethylmalonamide (PEMA). Anticonvulsant effect primarily from phenobarbital metabolite.
Hepatotoxic — more so than phenobarbital alone. Monitor liver enzymes. No advantage over phenobarbital in most cases. DEA Schedule IV in some jurisdictions.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–25 mg/kg | q8-12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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