Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Primidone is dosed at 8–15 mg/kg PO q8-12h initially, then q8h once titrated in dogs, per Papich, Saunders Handbook of Veterinary Drugs, 4th Ed (2016), p.703 — Primidone, Small Animal Dosage, Dogs and Cats. — LOCATOR CONVENTION 2026-08-07: the bare 'p.703' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.675; verified by finding the drug named there. If you are holding the book, turn to p.675. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Primidone is used in dogs for Seizures. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Primidone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Mysoline, Neurosyn
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 8–15 mg/kg | q8-12h initially, then q8h once titrated | Long-term | Seizures | Weak |
| Papich, Saunders Handbook of Veterinary Drugs, 4th Ed (2016), p.703 — Primidone, Small Animal Dosage, Dogs and Cats. — LOCATOR CONVENTION 2026-08-07: the bare 'p.703' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.675; verified by finding the drug named there. If you are holding the book, turn to p.675. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 8–10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.703 | • 8-10 mg/kg q8-12h as initial dose PO, then adjust via monitoring to 10-15 mg/kg |
| 10–15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.703 | • 8-10 mg/kg q8-12h as initial dose PO, then adjust via monitoring to 10-15 mg/kg |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Metabolized to phenobarbital (major active metabolite) and phenylethylmalonamide (PEMA). Anticonvulsant effect primarily from phenobarbital metabolite.
Hepatotoxic — more so than phenobarbital alone. Monitor liver enzymes. No advantage over phenobarbital in most cases. DEA Schedule IV in some jurisdictions.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Primidone dose range in dogs, with cited source references: PO 8–15 mg/kg q8-12h initially, then q8h once titrated. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Primidone in dogs: PO.
Cited course lengths for Primidone in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Primidone is indicated in dogs for: Seizures.
These are general warnings for Primidone across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic — more so than phenobarbital alone. Monitor liver enzymes. No advantage over phenobarbital in most cases. DEA Schedule IV in some jurisdictions.
Why a species-specific page? Primidone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.