Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Primidone is dosed at 8–15 mg/kg PO q8-12h initially, then q8h once titrated in dogs, per Papich, Saunders Handbook of Veterinary Drugs, 4th Ed (2016), p.703 — Primidone, Small Animal Dosage, Dogs and Cats.. Primidone is used in dogs for Seizures. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Primidone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Mysoline, Neurosyn
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 8–15 mg/kg | q8-12h initially, then q8h once titrated | Long-term | Seizures | Moderate | Papich, Saunders Handbook of Veterinary Drugs, 4th Ed (2016), p.703 — Primidone, Small Animal Dosage, Dogs and Cats. |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Metabolized to phenobarbital (major active metabolite) and phenylethylmalonamide (PEMA). Anticonvulsant effect primarily from phenobarbital metabolite.
Hepatotoxic — more so than phenobarbital alone. Monitor liver enzymes. No advantage over phenobarbital in most cases. DEA Schedule IV in some jurisdictions.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Primidone dose range in dogs, with cited source references: PO 8–15 mg/kg q8-12h initially, then q8h once titrated. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Primidone in dogs: PO.
Cited course lengths for Primidone in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Primidone is indicated in dogs for: Seizures.
These are general warnings for Primidone across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic — more so than phenobarbital alone. Monitor liver enzymes. No advantage over phenobarbital in most cases. DEA Schedule IV in some jurisdictions.
Why a species-specific page? Primidone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.