Skip to main content

Prucalopride

Motegrity, Resolor

Calculate dosage
Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Gastrointestinal

Routes

PO

Indications

chronic constipationGI stasisMegacolon

Mechanism of Action

Selective serotonin 5-HT4 receptor agonist stimulating colonic peristalsis and accelerating GI transit. High selectivity reduces cardiac risks.

Side effects & warnings

Used for chronic constipation, megacolon. Limited veterinary data. Diarrhea if dose too high. Fewer cardiac effects than cisapride due to 5-HT4 selectivity.

Species with Prucalopride dosing data (2 dose rules)

Cat (Domestic)Rabbit (Domestic)

Species references:All Cat (Domestic) drugsAll Rabbit (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Extrapolated×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

  • · Carpenter's Exotic Animal Formulary, 6th Ed
  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (1 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Cat (Domestic)PO0.1–0.5 mg/kgq24hWeakPlumb's Veterinary Drug Handbook, 9th Ed

Upgrade for Full Details

Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.

View Plans

More Gastrointestinal drugs

Calculate Dosage for Prucalopride