Cat · Felis catus · typical adult weight 2.50–7.00 kg
Riociguat is dosed at 0.5–1.5 mg/kg PO q8h in cats, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Riociguat is used in cats for Pulmonary hypertension (investigational). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Riociguat in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adempas
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1.5 mg/kg | q8h | Investigational | Pulmonary hypertension (investigational) | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Stimulates soluble guanylate cyclase (sGC) directly and sensitizes it to endogenous NO, increasing cGMP production and causing pulmonary vasodilation.
Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Riociguat dose range in cats, with cited source references: PO 0.5–1.5 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Riociguat in cats: PO.
Cited course lengths for Riociguat in cats include: Investigational. Duration depends on the indication — match it to the specific dose rule in the table above.
Riociguat is indicated in cats for: Pulmonary hypertension (investigational).
These are general warnings for Riociguat across species; consult the cat dosing table above for species-specific guidance. Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.
Why a species-specific page? Riociguat pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.