Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Riociguat is dosed at 0.5–2 mg/kg PO q8h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Riociguat is used in dogs for Pulmonary hypertension (alternative to sildenafil). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Riociguat in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adempas
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q8h | Long-term; titrate up from lowest dose | Pulmonary hypertension (alternative to sildenafil) | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Stimulates soluble guanylate cyclase (sGC) directly and sensitizes it to endogenous NO, increasing cGMP production and causing pulmonary vasodilation.
Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Riociguat dose range in dogs, with cited source references: PO 0.5–2 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Riociguat in dogs: PO.
Cited course lengths for Riociguat in dogs include: Long-term; titrate up from lowest dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Riociguat is indicated in dogs for: Pulmonary hypertension (alternative to sildenafil).
These are general warnings for Riociguat across species; consult the dog dosing table above for species-specific guidance. Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.
Why a species-specific page? Riociguat pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.