Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ambrisentan is dosed at 0.25–0.5 mg/kg PO q24h in dogs, per JVIM 2019; Veterinary Cardiology Literature. Ambrisentan is used in dogs for Pulmonary hypertension. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ambrisentan in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Letairis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–0.5 mg/kg | q24h | Long-term; monitor liver enzymes monthly initially | Pulmonary hypertension | Weak | JVIM 2019; Veterinary Cardiology Literature |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selective endothelin type A (ETA) receptor antagonist that blocks endothelin-1 mediated vasoconstriction and smooth muscle proliferation in pulmonary vasculature.
Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ambrisentan dose range in dogs, with cited source references: PO 0.25–0.5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ambrisentan in dogs: PO.
Cited course lengths for Ambrisentan in dogs include: Long-term; monitor liver enzymes monthly initially. Duration depends on the indication — match it to the specific dose rule in the table above.
Ambrisentan is indicated in dogs for: Pulmonary hypertension.
These are general warnings for Ambrisentan across species; consult the dog dosing table above for species-specific guidance. Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.
Why a species-specific page? Ambrisentan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.