Ambrisentan for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ambrisentan is used in dog for Pulmonary hypertension. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ambrisentan in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Letairis
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–0.5 mg/kg | q24h | Long-term; monitor liver enzymes monthly initially | Pulmonary hypertension | Weak | JVIM 2019; Veterinary Cardiology Literature |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Selective endothelin type A (ETA) receptor antagonist that blocks endothelin-1 mediated vasoconstriction and smooth muscle proliferation in pulmonary vasculature.
Side effects & warnings
Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Respiratory drugs with dog dosing
Ambrisentan dosing in other species
Why a species-specific page? Ambrisentan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.