Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Doxapram is dosed at 1.1–11 mg/kg IV Once IV; may repeat in 15-20 min in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.426, Doxapram monograph spanning p.426-428; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Doxapram monograph, printed p.426-428; the earlier note claiming no held source contained this figure was wrong and has been removed. — figure located 2026-08-05 at Plumb's 10th ed printed p.428, Doxapram monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Doxapram is used in dogs for Post-anaesthetic respiratory depression - 1.1 mg/kg with GAS, 5.5-11 mg/kg with BARBITURATE anaesthesia. NOT for neonatal resuscitation, Neonatal resuscitation, post-anesthetic apnea, Neonatal puppy resuscitation (cesarean section). Routes documented in dogs: IV, SC, SL, or umbilical. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 3 cited dose rules for Doxapram in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dopram
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1.1–11 mg/kg | Once IV; may repeat in 15-20 min |
| Single dose, repeat once if needed |
| Post-anaesthetic respiratory depression - 1.1 mg/kg with GAS, 5.5-11 mg/kg with BARBITURATE anaesthesia. NOT for neonatal resuscitation |
| Moderate |
| Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.426, Doxapram monograph spanning p.426-428; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Doxapram monograph, printed p.426-428; the earlier note claiming no held source contained this figure was wrong and has been removed. — figure located 2026-08-05 at Plumb's 10th ed printed p.428, Doxapram monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| IV | 1.1–10 mg/kg | once; may repeat in 15-20 min | Single dose; may repeat | Neonatal resuscitation, post-anesthetic apnea | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.426, Doxapram monograph spanning p.426-428; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.428, Doxapram monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| SC, SL, or umbilical | 1–5 mg/puppy (NOT mg/kg) | once | Single dose | Neonatal puppy resuscitation (cesarean section) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.426, Doxapram monograph spanning p.426-428; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Stimulates peripheral carotid chemoreceptors and central medullary respiratory centers, increasing tidal volume and respiratory rate.
Short duration of action (minutes). Use for neonatal resuscitation or post-anesthetic apnea. May cause hypertension, tachycardia, and seizures at high doses. Ensure adequate airway before use.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Doxapram dose ranges in dogs, with cited source references: IV 1.1–11 mg/kg Once IV; may repeat in 15-20 min; IV 1.1–10 mg/kg once; may repeat in 15-20 min; SC, SL, or umbilical 1–5 mg/puppy (NOT mg/kg) once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Doxapram in dogs: IV, SC, SL, or umbilical.
Cited course lengths for Doxapram in dogs include: Single dose, repeat once if needed; Single dose; may repeat; Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Doxapram is indicated in dogs for: Post-anaesthetic respiratory depression - 1.1 mg/kg with GAS, 5.5-11 mg/kg with BARBITURATE anaesthesia. NOT for neonatal resuscitation, Neonatal resuscitation, post-anesthetic apnea, Neonatal puppy resuscitation (cesarean section).
These are general warnings for Doxapram across species; consult the dog dosing table above for species-specific guidance. Short duration of action (minutes). Use for neonatal resuscitation or post-anesthetic apnea. May cause hypertension, tachycardia, and seizures at high doses. Ensure adequate airway before use.
Why a species-specific page? Doxapram pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.