ExoticRx · exoticrx.com/drugs/selegiline
US brand names:Anipryl, Eldepryl
Selegiline is dosed at 0.5–1 mg/kg PO q24h morning in dogs, per ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01).. Verify against current literature before clinical use.
Irreversible monoamine oxidase B (MAO-B) inhibitor increasing dopamine levels in the brain. Neuroprotective and cognitive-enhancing effects.
FDA-approved for canine cognitive dysfunction syndrome (CDS) and canine pituitary-dependent Cushing's. Do not combine with SSRIs, TCAs, or meperidine (serotonin syndrome). 2-4 weeks for effect.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q24h morning | Strong | ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). |
| Dog (Domestic) | PO | 1–2 mg/kg | q24h morning | Moderate | ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.