Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Selegiline is dosed at 1–2 mg/kg PO q24h morning in dogs, per ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). — Plumb's 10th ed (held) printed p.1151, Selegiline monograph spanning p.1151-1152; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Selegiline is used in dogs for Pituitary-dependent hyperadrenocorticism, Cognitive dysfunction syndrome. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Selegiline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Anipryl, Eldepryl
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q24h morning | Long-term | Pituitary-dependent hyperadrenocorticism | Moderate | ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). — Plumb's 10th ed (held) printed p.1151, Selegiline monograph spanning p.1151-1152; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 0.5–1 mg/kg | q24h morning | Long-term | Cognitive dysfunction syndrome | Strong | ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). — Plumb's 10th ed (held) printed p.1151, Selegiline monograph spanning p.1151-1152; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.388 | 0.5-1 mg/kg p.o. q24h for a minimum of 2 months |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.751 | • Begin with 1 mg/kg q24h PO. If there is no response within 2 months, increase |
| 2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.751 | dose to maximum of 2 mg/kg q24h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Irreversible monoamine oxidase B (MAO-B) inhibitor increasing dopamine levels in the brain. Neuroprotective and cognitive-enhancing effects.
FDA-approved for canine cognitive dysfunction syndrome (CDS) and canine pituitary-dependent Cushing's. Do not combine with SSRIs, TCAs, or meperidine (serotonin syndrome). 2-4 weeks for effect.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Selegiline dose ranges in dogs, with cited source references: PO 1–2 mg/kg q24h morning; PO 0.5–1 mg/kg q24h morning. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Selegiline in dogs: PO.
Cited course lengths for Selegiline in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Selegiline is indicated in dogs for: Pituitary-dependent hyperadrenocorticism, Cognitive dysfunction syndrome.
These are general warnings for Selegiline across species; consult the dog dosing table above for species-specific guidance. FDA-approved for canine cognitive dysfunction syndrome (CDS) and canine pituitary-dependent Cushing's. Do not combine with SSRIs, TCAs, or meperidine (serotonin syndrome). 2-4 weeks for effect.
Why a species-specific page? Selegiline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.