Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Selegiline is dosed at 0.5–1 mg/kg PO q24h morning in dogs, per ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01).. Selegiline is used in dogs for Cognitive dysfunction syndrome, Pituitary-dependent hyperadrenocorticism. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Selegiline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Anipryl, Eldepryl
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q24h morning | Long-term | Cognitive dysfunction syndrome | Strong | ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). |
| PO | 1–2 mg/kg | q24h morning | Long-term | Pituitary-dependent hyperadrenocorticism | Moderate | ANIPRYL- Selegiline Hydrochloride Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84e25a59-1db6-42bf-b27e-a25c4883a141 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1180 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Irreversible monoamine oxidase B (MAO-B) inhibitor increasing dopamine levels in the brain. Neuroprotective and cognitive-enhancing effects.
FDA-approved for canine cognitive dysfunction syndrome (CDS) and canine pituitary-dependent Cushing's. Do not combine with SSRIs, TCAs, or meperidine (serotonin syndrome). 2-4 weeks for effect.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Selegiline dose ranges in dogs, with cited source references: PO 0.5–1 mg/kg q24h morning; PO 1–2 mg/kg q24h morning. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Selegiline in dogs: PO.
Cited course lengths for Selegiline in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Selegiline is indicated in dogs for: Cognitive dysfunction syndrome, Pituitary-dependent hyperadrenocorticism.
These are general warnings for Selegiline across species; consult the dog dosing table above for species-specific guidance. FDA-approved for canine cognitive dysfunction syndrome (CDS) and canine pituitary-dependent Cushing's. Do not combine with SSRIs, TCAs, or meperidine (serotonin syndrome). 2-4 weeks for effect.
Why a species-specific page? Selegiline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.