ExoticRx · exoticrx.com/drugs/sevoflurane
US brand names:SevoFlo, Sevofrane
Sevoflurane is dosed at 1–5 % inhalation continuous, to effect in sugar gliders, per Ness RD, Johnson-Delaney C. Sugar gliders. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 3rd ed., Saunders/Elsevier, St. Louis, MO; 2012:393-410. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.709. Verify against current literature before clinical use.
Enhances GABA-A and glycine receptor activity while inhibiting NMDA receptors and nicotinic acetylcholine receptors. Produces dose-dependent anesthesia.
Requires precision vaporizer. Dose-dependent cardiovascular/respiratory depression. Rapid induction and recovery (low blood-gas solubility). Non-irritating to airways. Compound A production with soda lime (low flow caution).
Species references:All African Clawed Frog drugsAll Axolotl drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugsAll Fire Salamander drugsAll Houston Toad drugsAll Sugar Glider drugsAll White's Tree Frog drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 8 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | INHALATION | 2–3.5 % (MAC 2.4%) | Continuous | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.1156, Sevoflurane monograph spanning p.1156-1158.Compilation only — we have not located an independent source that prints this figure. |
| Cat (Domestic) | INHALATION | 2.5–4 % (MAC 2.6%) | Continuous | Strong | Shaughnessy MR, Hofmeister EH. A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats. Vet Anaesth Analg. 2014;41(1):1-13. doi:10.1111/vaa.12083 — Plumb's 10th ed printed p.1156, Sevoflurane monograph spanning p.1156-1158. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.