ExoticRx · exoticrx.com/drugs/sevoflurane
US brand names:SevoFlo, Sevofrane
Sevoflurane is dosed at 1–5 % inhalation continuous, to effect in sugar gliders, per Ness RD, Johnson-Delaney C. Sugar gliders. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 3rd ed., Saunders/Elsevier, St. Louis, MO; 2012:393-410. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.709 — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery — ISBN 9780323484350, https://openlibrary.org/isbn/9780323484350. Verify against current literature before clinical use.
Enhances GABA-A and glycine receptor activity while inhibiting NMDA receptors and nicotinic acetylcholine receptors. Produces dose-dependent anesthesia.
Requires precision vaporizer. Dose-dependent cardiovascular/respiratory depression. Rapid induction and recovery (low blood-gas solubility). Non-irritating to airways. Compound A production with soda lime (low flow caution).
Species references:All African Clawed Frog drugsAll Axolotl drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugsAll Fire Salamander drugsAll Houston Toad drugsAll Sugar Glider drugsAll White's Tree Frog drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 8 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | INHALATION | 2–3.5 % (MAC 2.4%) | Continuous | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1156, Sevoflurane monograph spanning p.1156-1158; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | INHALATION | 2.5–4 % (MAC 2.6%) | Continuous | Strong | Shaughnessy MR, Hofmeister EH. A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats. Vet Anaesth Analg. 2014;41(1):1-13. doi:10.1111/vaa.12083 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1185 (2026-08-01). — Plumb's 10th ed (held) printed p.1156, Sevoflurane monograph spanning p.1156-1158; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.