ExoticRx · exoticrx.com/drugs/sevoflurane
US brand names:SevoFlo, Sevofrane
Sevoflurane is dosed at 2–3.5 % (MAC 2.4%) INHALATION Continuous in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Enhances GABA-A and glycine receptor activity while inhibiting NMDA receptors and nicotinic acetylcholine receptors. Produces dose-dependent anesthesia.
Requires precision vaporizer. Dose-dependent cardiovascular/respiratory depression. Rapid induction and recovery (low blood-gas solubility). Non-irritating to airways. Compound A production with soda lime (low flow caution).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | INHALATION | 2–3.5 % (MAC 2.4%) | Continuous | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | INHALATION | 2.5–4 % (MAC 2.6%) | Continuous | Strong | Shaughnessy MR, Hofmeister EH. A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats. Vet Anaesth Analg. 2014;41(1):1-13. doi:10.1111/vaa.12083 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1185 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.