Cat · Felis catus · typical adult weight 2.50–7.00 kg
Silymarin is dosed at 5–10 mg/kg PO q24h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Silymarin is used in cats for Hepatoprotection, Hepatoprotection, liver disease support. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 2 cited dose rules for Silymarin in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Marin, Milk Thistle, Denamarin, Milk Thistle (Silymarin)
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | Long-term | Hepatoprotection | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 5–15 mg/kg | q24h | Long-term for chronic liver disease | Hepatoprotection, liver disease support | Weak | Papich MG. Saunders Handbook of Veterinary Drugs, Silymarin monograph, printed p.728 (corpus PDF p.756) |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Antioxidant and anti-inflammatory flavonoid from milk thistle. Stabilizes hepatocyte membranes, stimulates protein synthesis, and scavenges free radicals.
Generally safe. Often combined with SAMe (Denamarin). Evidence for hepatoprotection moderate. GI upset at high doses. May interact with P-glycoprotein substrates.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Silymarin dose ranges in cats, with cited source references: PO 5–10 mg/kg q24h; PO 5–15 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Silymarin in cats: PO.
Cited course lengths for Silymarin in cats include: Long-term; Long-term for chronic liver disease. Duration depends on the indication — match it to the specific dose rule in the table above.
Silymarin is indicated in cats for: Hepatoprotection, Hepatoprotection, liver disease support.
These are general warnings for Silymarin across species; consult the cat dosing table above for species-specific guidance. Generally safe. Often combined with SAMe (Denamarin). Evidence for hepatoprotection moderate. GI upset at high doses. May interact with P-glycoprotein substrates.
Why a species-specific page? Silymarin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.