Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Silymarin is used in dog for Hepatoprotection, Hepatoprotection, liver disease support. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Silymarin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Marin, Milk Thistle, Denamarin, Milk Thistle (Silymarin)
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | Long-term | Hepatoprotection | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 20–50 mg/kg | q24h (divided q8-12h preferred) | Long-term for chronic liver disease | Hepatoprotection, liver disease support | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Antioxidant and anti-inflammatory flavonoid from milk thistle. Stabilizes hepatocyte membranes, stimulates protein synthesis, and scavenges free radicals.
Generally safe. Often combined with SAMe (Denamarin). Evidence for hepatoprotection moderate. GI upset at high doses. May interact with P-glycoprotein substrates.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Silymarin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.