ExoticRx · exoticrx.com/drugs/sodium-polystyrene-sulfonate
US brand names:Kayexalate, Kionex
Sodium Polystyrene Sulfonate is dosed at 500–1000 mg/kg PO q8-12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Cation exchange resin that exchanges sodium for potassium in the GI tract, increasing fecal potassium excretion and lowering serum potassium.
Risk of sodium overload in cardiac patients. Intestinal necrosis reported with sorbitol. Monitor electrolytes closely. Constipation common.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.