ExoticRx · exoticrx.com/drugs/tranexamic-acid
US brand names:Cyklokapron, Lysteda
Tranexamic Acid is dosed at 10–20 mg/kg IV Slow IV over 15-20 min; may repeat in 6-8h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) - Tranexamic Acid, Dosages, DOGS, corpus p.1292 — LOCATOR CONVENTION 2026-08-07: the bare 'p.1292' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1265; verified by finding the drug named there. If you are holding the book, turn to p.1265. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Synthetic lysine analog that competitively inhibits plasminogen activation, preventing fibrin clot degradation. Stabilizes formed clots.
Used for hemorrhage and coagulopathy. Thrombotic risk — avoid in DIC. Dose-dependent seizure risk (especially in renal disease). Slow IV injection.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 10–20 mg/kg | Slow IV over 15-20 min; may repeat in 6-8h | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) - Tranexamic Acid, Dosages, DOGS, corpus p.1292 — LOCATOR CONVENTION 2026-08-07: the bare 'p.1292' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1265; verified by finding the drug named there. If you are holding the book, turn to p.1265. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | IV | 10–15 mg/kg | IV slowly | Weak | Padin BR, Fantoni DT. Pilot study to assess intraoperative blood loss in cats after the administration of tranexamic acid during resection of carcinomas and sarcomas. Presented at: International (European) Soc Feline Med (ISFM); 2015. Distributed by John Wiley & Sons, Inc. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1292 (2026-08-01). — Plumb's 10th ed (held) printed p.1264, Tranexamic Acid monograph spanning p.1264-1265; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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