ExoticRx · exoticrx.com/drugs/trifluridine-ophthalmic
US brand names:Viroptic
Incorporated into viral DNA inhibiting thymidylate synthetase and viral DNA polymerase. Active against HSV-1, HSV-2, and some adenoviruses.
Ophthalmic use only. Local irritation and stinging. Punctal plugging may enhance effect. Commonly used in cats for FHV-1 keratitis.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | Ophthalmic | Epithelial toxicity if prolonged | q4-6h initially, then q8h | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1408, Trifluridine Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | Ophthalmic | See the cited source for the printed regimen | q2-3h for 48 h, then 4-5 times daily | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1408, Trifluridine Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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