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Xylazine for Sheep

Livestock · Ovis aries · typical adult weight 30.00–120.00 kg

Xylazine is used in sheep for Sedation, Sedation, chemical restraint. Routes documented in sheep: IM. A typical adult sheep weighs 30.00–120.00 kg. ExoticRx lists 2 cited dose rules for Xylazine in sheep, drawn from published veterinary references. Verify against current literature before clinical use.

Trade names: Rompun, AnaSed

Dose ranges

RouteDoseFrequencyDurationIndicationEvidenceSource
IM0.1–0.2 mg/kgsingle doseSedationModeratePlumb's Veterinary Drug Handbook, 9th Ed
IM0.05–0.1 mg/kgAs neededSingle doseSedation, chemical restraintModeratePlumb's Veterinary Drug Handbook

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These ranges are per kg. Enter your sheep's weight to get the precise dose and draw-up volume — unit and concentration math done for you.

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Mechanism of action

Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.

Side effects & warnings

Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.

Species-specific contraindications and adverse-reaction reports for sheep may differ from canine / feline reference data — consult the primary citations listed with each rule.

Xylazine dosing in other species

Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in sheep — the rules above are the citations specific to this species, not generic recommendations.

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.