Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Xylazine is dosed at 0.1–0.2 mg/kg IM single dose in cattle, per Walz P. Practical management of pain in cattle. Presented at: ABVP; 2006. PMID: 42126006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01). — Plumb's 10th ed (held) printed p.1319, Xylazine monograph spanning p.1319-1323; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Xylazine is used in cattle for Sedation, Sedation, analgesia. Routes documented in cattle: IM, IV. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 2 cited dose rules for Xylazine in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rompun, AnaSed
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IM | 0.1–0.2 mg/kg | single dose | Sedation | Strong | Walz P. Practical management of pain in cattle. Presented at: ABVP; 2006. PMID: 42126006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01). — Plumb's 10th ed (held) printed p.1319, Xylazine monograph spanning p.1319-1323; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| IV | 0.05–0.1 mg/kg | single dose | Sedation, analgesia | Strong | Walz P. Practical management of pain in cattle. Presented at: ABVP; 2006. PMID: 42126006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01). — Plumb's 10th ed (held) printed p.1319, Xylazine monograph spanning p.1319-1323; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.1–0.2 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | • 0.1-0.2 mg/kg IM. |
| 0.03–0.1 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | • 0.03-0.1 mg/kg IV. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Xylazine dose ranges in cattle, with cited source references: IM 0.1–0.2 mg/kg single dose; IV 0.05–0.1 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Xylazine in cattle: IM, IV.
Xylazine is indicated in cattle for: Sedation, Sedation, analgesia.
These are general warnings for Xylazine across species; consult the cattle dosing table above for species-specific guidance. Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.