Xylazine for Horse
Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Xylazine is used in horse for Sedation, analgesia, preanesthesia. Routes documented in horse: IV. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 1 cited dose rule for Xylazine in horse, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Rompun, AnaSed
Dose ranges
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV | 0.5–1.1 mg/kg | single dose | Sedation, analgesia, preanesthesia | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your horse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Side effects & warnings
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for horse may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Sedative drugs with horse dosing
Xylazine dosing in other species
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horse — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.