Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Xylazine is dosed at 0.5–1.1 mg/kg IV single dose in horses, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01).. Xylazine is used in horses for Sedation, analgesia, preanesthesia. Routes documented in horses: IV. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 1 cited dose rule for Xylazine in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rompun, AnaSed
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV | 0.5–1.1 mg/kg | single dose | Sedation, analgesia, preanesthesia | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01). |
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Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Xylazine dose range in horses, with cited source references: IV 0.5–1.1 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Xylazine in horses: IV.
Xylazine is indicated in horses for: Sedation, analgesia, preanesthesia.
These are general warnings for Xylazine across species; consult the horse dosing table above for species-specific guidance. Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.