Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Xylazine is dosed at 0.5–1.1 mg/kg IV single dose in horses, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01). — Plumb's 10th ed (held) printed p.1319, Xylazine monograph spanning p.1319-1323; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Xylazine is used in horses for Sedation, analgesia, preanesthesia. Routes documented in horses: IV. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 1 cited dose rule for Xylazine in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rompun, AnaSed
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV | 0.5–1.1 mg/kg | single dose | Sedation, analgesia, preanesthesia | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1349 (2026-08-01). — Plumb's 10th ed (held) printed p.1319, Xylazine monograph spanning p.1319-1323; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | consists of 500 mg xylazine and 2 g ketamine added to 1 L of 5% guaifenesis in |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | • Standing chemical restraint: 0.5-1.0 mg/kg IV bolus. (The intravenous dose also |
| 0.5–1.1 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | • 0.5-1.1 mg/kg IV, followed by (if necessary) 0.72 mg/kg/hour constant-rate |
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Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Xylazine dose range in horses, with cited source references: IV 0.5–1.1 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Xylazine in horses: IV.
Xylazine is indicated in horses for: Sedation, analgesia, preanesthesia.
These are general warnings for Xylazine across species; consult the horse dosing table above for species-specific guidance. Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.72 |
| IV |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 |
| • 0.5-1.1 mg/kg IV, followed by (if necessary) 0.72 mg/kg/hour constant-rate |
| 0.3–0.5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | • For colic pain: 0.3-0.5 mg/kg IV (150-250 mg IV for average-size horse). |
| 0.125 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | administer 0.125 mg/kg yohimbine to speed up recovery. |
| 1–2 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | • 1-2 mg/kg IM. |
| Dose (ml/kg) | Route | Source | As printed |
|---|---|---|---|
| 1.1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | dextrose. It is administered at a rate of 1.1 mL/kg for induction, followed by |
| 2–4 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.879 | 2-4 mL/kg/hour for maintenance. Recovery usually occurs in 25-30 minutes, or |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.