Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Ceftiofur Crystalline Free Acid (Long-Acting) is dosed at 6.6 mg/kg SC single dose at base of ear in cattle, per EXCEDE STERILE- ceftiofur injection, suspension [US cattle product label]. Kalamazoo, MI: Zoetis Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9922e056-dcb0-46fd-bb56-9863bb0a189e — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.250 (2026-08-01). — Plumb's 10th ed (held) printed p.223, Ceftiofur Crystalline Free Acid monograph spanning p.221-223; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.313a (Ceftiofur crystalline free acid), conditions of use for Cattle: 6.6-6.6 mg/kg. Related tolerances: 21 CFR § 556.113. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.313a — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Ceftiofur Crystalline Free Acid (Long-Acting) is used in cattle for Bovine respiratory disease. Routes documented in cattle: SC. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 1 cited dose rule for Ceftiofur Crystalline Free Acid (Long-Acting) in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Excede
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| SC | 6.6 mg/kg | single dose at base of ear | Bovine respiratory disease | Strong | EXCEDE STERILE- ceftiofur injection, suspension [US cattle product label]. Kalamazoo, MI: Zoetis Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9922e056-dcb0-46fd-bb56-9863bb0a189e — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.250 (2026-08-01). — Plumb's 10th ed (held) printed p.223, Ceftiofur Crystalline Free Acid monograph spanning p.221-223; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.313a (Ceftiofur crystalline free acid), conditions of use for Cattle: 6.6-6.6 mg/kg. Related tolerances: 21 CFR § 556.113. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.313a — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 6.6 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.166 | • 6.6 mg/kg, with a single SQ injection in the middle third of the posterior aspect |
| 1.1–2.2 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.170 | • BRD: 1.1-2.2 mg/kg (0.5-1.0 mg/pound) q24h for 3 days IM. Additional doses |
| 2.2 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.168 | • Treatment of postpartum metritis: 2.2 mg/kg once daily for 5 days SQ or IM. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Long-acting crystalline formulation provides sustained therapeutic concentrations for up to 7 days from a single injection.
Not for use in dairy cattle 20 months of age or older or in veal calves. Single injection site; do not exceed 1 injection site per animal. Do not use in horses intended for food.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ceftiofur Crystalline Free Acid (Long-Acting) dose range in cattle, with cited source references: SC 6.6 mg/kg single dose at base of ear. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ceftiofur Crystalline Free Acid (Long-Acting) in cattle: SC.
Ceftiofur Crystalline Free Acid (Long-Acting) is indicated in cattle for: Bovine respiratory disease.
These are general warnings for Ceftiofur Crystalline Free Acid (Long-Acting) across species; consult the cattle dosing table above for species-specific guidance. Not for use in dairy cattle 20 months of age or older or in veal calves. Single injection site; do not exceed 1 injection site per animal. Do not use in horses intended for food.
Why a species-specific page? Ceftiofur Crystalline Free Acid (Long-Acting) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.