Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Florfenicol is dosed at 20 mg/kg IM Repeat once after 48 h, 2 doses total, neck IM in cattle, per NUFLOR - Florfenicol Injection, Solution [US Product Label]. Intervet Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c1aeba99-224d-4957-80ec-87212df5dfaf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.556 (2026-08-01). — Plumb's 10th ed (held) printed p.529, Florfenicol monograph spanning p.528-529; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.955 (Florfenicol), conditions of use for Beef and non-lactating dairy cattle: 20-20 mg/kg. Related tolerances: 21 CFR § 556.283. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.955 — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Florfenicol is used in cattle for Bovine respiratory disease. Routes documented in cattle: IM, SC. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 2 cited dose rules for Florfenicol in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nuflor, Aquaflor
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 20 mg/kg | Repeat once after 48 h, 2 doses total, neck IM | 2 doses | Bovine respiratory disease | Strong | NUFLOR - Florfenicol Injection, Solution [US Product Label]. Intervet Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c1aeba99-224d-4957-80ec-87212df5dfaf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.556 (2026-08-01). — Plumb's 10th ed (held) printed p.529, Florfenicol monograph spanning p.528-529; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.955 (Florfenicol), conditions of use for Beef and non-lactating dairy cattle: 20-20 mg/kg. Related tolerances: 21 CFR § 556.283. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.955 — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| SC | 40 mg/kg | single dose | — | Bovine respiratory disease | Strong | NUFLOR - Florfenicol Injection, Solution [US Product Label]. Intervet Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c1aeba99-224d-4957-80ec-87212df5dfaf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.556 (2026-08-01). — Plumb's 10th ed (held) printed p.529, Florfenicol monograph spanning p.528-529; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.955 (Florfenicol), conditions of use for Beef and non-lactating dairy cattle: 40-40 mg/kg. Related tolerances: 21 CFR § 556.283. Retrieved from the eCFR API, snapshot 2026-01-01. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.356 | • 20 mg/kg q48h SQ or IM (in the neck). |
| 40 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.356 | • 40 mg/kg SQ as a single injection or q72h SQ in the neck region (also combined with |
| 2.2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.356 | flunixin at 2.2 mg/kg and Nuflor Gold at 40 mg/kg single injection). |
| 40 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.356 | flunixin at 2.2 mg/kg and Nuflor Gold at 40 mg/kg single injection). |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Binds 50S ribosomal subunit inhibiting peptidyl transferase. Fluorinated analog of chloramphenicol without aplastic anemia risk. Bacteriostatic.
Veterinary-labeled product. Injection site reactions common. Do not use in dairy cattle of breeding age. GI upset possible.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Florfenicol dose ranges in cattle, with cited source references: IM 20 mg/kg Repeat once after 48 h, 2 doses total, neck IM; SC 40 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Florfenicol in cattle: IM, SC.
Cited course lengths for Florfenicol in cattle include: 2 doses. Duration depends on the indication — match it to the specific dose rule in the table above.
Florfenicol is indicated in cattle for: Bovine respiratory disease.
These are general warnings for Florfenicol across species; consult the cattle dosing table above for species-specific guidance. Veterinary-labeled product. Injection site reactions common. Do not use in dairy cattle of breeding age. GI upset possible.
Why a species-specific page? Florfenicol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.