Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Danofloxacin (Livestock) is dosed at 6–8 mg/kg SC 8 mg/kg once, OR 6 mg/kg repeated once at 48h in cattle, per FDA NADA 141-207 — ADVOCIN (DANOFLOXACIN MESYLATE) INJECTION, SOLUTION [ZOETIS INC.] — https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d22c22fc-d530-423c-8d78-ca95fe195ba1 NOTE: label located and covers this species, but does not print this figure; unit difference does not explain it. Needs review.. Danofloxacin (Livestock) is used in cattle for Bovine respiratory disease. Routes documented in cattle: SC. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 1 cited dose rule for Danofloxacin (Livestock) in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Advocin, A180
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 6–8 mg/kg | 8 mg/kg once, OR 6 mg/kg repeated once at 48h | Two alternative label regimens — do not combine. Single 8 mg/kg dose, or 6 mg/kg followed by one repeat at approximately 48 hours. | Bovine respiratory disease | Strong | FDA NADA 141-207 — ADVOCIN (DANOFLOXACIN MESYLATE) INJECTION, SOLUTION [ZOETIS INC.] — https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d22c22fc-d530-423c-8d78-ca95fe195ba1 NOTE: label located and covers this species, but does not print this figure; unit difference does not explain it. Needs review. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 6 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.233 | • 6 mg/kg (1.5 mL per 100 pounds), once per 48 hours, SQ. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Fluoroquinolone with concentration-dependent bactericidal activity. Inhibits DNA gyrase and topoisomerase IV. Achieves high pulmonary concentrations.
For cattle only (BRD treatment). SC injection in the neck only. Not for use in dairy cattle 20 months of age or older. Observe withdrawal period for slaughter.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Danofloxacin (Livestock) dose range in cattle, with cited source references: SC 6–8 mg/kg 8 mg/kg once, OR 6 mg/kg repeated once at 48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Danofloxacin (Livestock) in cattle: SC.
Cited course lengths for Danofloxacin (Livestock) in cattle include: Two alternative label regimens — do not combine. Single 8 mg/kg dose, or 6 mg/kg followed by one repeat at approximately 48 hours.. Duration depends on the indication — match it to the specific dose rule in the table above.
Danofloxacin (Livestock) is indicated in cattle for: Bovine respiratory disease.
These are general warnings for Danofloxacin (Livestock) across species; consult the cattle dosing table above for species-specific guidance. For cattle only (BRD treatment). SC injection in the neck only. Not for use in dairy cattle 20 months of age or older. Observe withdrawal period for slaughter.
Why a species-specific page? Danofloxacin (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.