Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cyclosporine Ophthalmic 0.05% is dosed at 0.2 % ointment, 1/4 inch strip per eye Ophthalmic q12h long-term; q24h only w/ caution in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1357, Cyclosporine Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Cyclosporine Ophthalmic monograph, printed p.1357; the earlier note claiming no held source contained this figure was wrong and has been removed. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Cyclosporine Ophthalmic 0.05% is used in dogs for KCS (dry eye). Routes documented in dogs: Ophthalmic. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Cyclosporine Ophthalmic 0.05% in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Restasis, Optimmune, Ciclosporin Ophthalmic
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Ophthalmic | 0.2 % ointment, 1/4 inch strip per eye | q12h long-term; q24h only w/ caution | Lifelong | KCS (dry eye) | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1357, Cyclosporine Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Cyclosporine Ophthalmic monograph, printed p.1357; the earlier note claiming no held source contained this figure was wrong and has been removed. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 3–7 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.224 | • 3-7 mg/kg/day PO. The typical starting dose is 5 mg/kg/day PO. After induc- |
| 5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.224 | • 3-7 mg/kg/day PO. The typical starting dose is 5 mg/kg/day PO. After induc- |
| 5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.224 | low as 5 mg/kg every other day to every third day. |
| 5–8 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.224 | and more frequent administration have been used (5-8 mg/kg, every 12 hours). |
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Calcineurin inhibitor that suppresses T-cell mediated inflammation in the lacrimal gland. Increases tear production by reducing immune-mediated destruction of lacrimal tissue.
Standard of care for canine keratoconjunctivitis sicca. May take 4-6 weeks for full effect. Transient stinging on application. Also available as 0.2% veterinary formulation (Optimmune).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cyclosporine Ophthalmic 0.05% dose range in dogs, with cited source references: Ophthalmic 0.2 % ointment, 1/4 inch strip per eye q12h long-term; q24h only w/ caution. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cyclosporine Ophthalmic 0.05% in dogs: Ophthalmic.
Cited course lengths for Cyclosporine Ophthalmic 0.05% in dogs include: Lifelong. Duration depends on the indication — match it to the specific dose rule in the table above.
Cyclosporine Ophthalmic 0.05% is indicated in dogs for: KCS (dry eye).
These are general warnings for Cyclosporine Ophthalmic 0.05% across species; consult the dog dosing table above for species-specific guidance. Standard of care for canine keratoconjunctivitis sicca. May take 4-6 weeks for full effect. Transient stinging on application. Also available as 0.2% veterinary formulation (Optimmune).
Why a species-specific page? Cyclosporine Ophthalmic 0.05% pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 7–10 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.224 |
| higher (e.g., 7-10 mg/kg q12h PO). |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.