ExoticRx · exoticrx.com/drugs/demecarium-bromide-ophthalmic
US brand names:Humorsol
Long-acting irreversible cholinesterase inhibitor. Produces intense, prolonged miosis and sustained reduction in intraocular pressure by enhancing trabecular outflow.
Rare — limited availability. Very potent miotic. Systemic cholinergic effects possible. Use for refractory glaucoma when other agents fail. Monitor for GI and respiratory signs.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Ophthalmic | Very potent long-acting miotic | 1 drop affected eye q12h-q24h | Weak | (Gum et al., 1993a) - Gelatt cites author-date, not superscript numbers; corroborated on ophtho p.1540: 'The use of demecarium bromide 0.25% topically twice daily showed a median vision retention time of 1,313 days (Binder et al., 2007).' — Verified against Veterinary Ophthalmology (Gelatt), 6th Ed, p.476 (2026-08-01). |
| Cat (Domestic) | Ophthalmic | Feline glaucoma is rare | 1 drop affected eye q24h | Anecdotal | Gelatt KN, Veterinary Ophthalmology, 6th Ed |
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