ExoticRx · exoticrx.com/drugs/digoxin-immune-fab
US brand names:Digibind, DigiFab
Ovine digoxin-specific Fab antibody fragments that bind free digoxin/digitoxin with high affinity, preventing receptor binding.
Specific antidote for digoxin/digitoxin toxicosis. Very expensive. Dose based on amount of digoxin ingested or serum level. Effect within 30 minutes IV. Rarely available in veterinary settings.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | Dose calculated from digoxin ingested or serum level | Based on digoxin body load | Moderate | Pao-Franco A, Hammond TN, Weatherton LK, De Clementi C, Forney SD. Successful use of digoxin-specific immune Fab in the treatment of severe Nerium oleander toxicosis in a dog. J Vet Emerg Crit Care. 2017;27(5):596-604. doi:10.1111/vec.12634 — Verified against Riviere & Papich, Veterinary Pharmacology and Therapeutics, 10th Ed, p.534 (2026-08-01). |
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