ExoticRx · exoticrx.com/drugs/dorzolamide
US brand names:Trusopt, Cosopt(combination)
Dorzolamide is dosed at 1 drop/eye TOPICAL q8h in dogs, per Gelatt KN, MacKay EO. Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet Ophthalmol. 2001;4:61-67. doi:10.1046/j.1463-5224.2001.00141.x; Cawrse MA, Ward DA, Hendrix DV. Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Am J Vet Res. 2001;62:859-863. doi:10.2460/ajvr.2001.62.859 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1389 (2026-08-01).. Verify against current literature before clinical use.
Inhibits carbonic anhydrase II in the ciliary body, reducing aqueous humor production and lowering intraocular pressure.
Stinging on application. May be used alone or with timolol (Cosopt). Primary treatment for glaucoma in dogs. Less effective in cats and horses. Apply q8-12h.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | 1 drop/eye | q8h | Strong | Gelatt KN, MacKay EO. Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet Ophthalmol. 2001;4:61-67. doi:10.1046/j.1463-5224.2001.00141.x; Cawrse MA, Ward DA, Hendrix DV. Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Am J Vet Res. 2001;62:859-863. doi:10.2460/ajvr.2001.62.859 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1389 (2026-08-01). |
| Cat (Domestic) | TOPICAL | 1 drop/eye | q8-12h | Weak |
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