ExoticRx · exoticrx.com/drugs/dorzolamide
US brand names:Trusopt, Cosopt(combination)
Dorzolamide is dosed at 1 drop of 1% solution (dilute 2% product), topical topical ophthalmic q12h in pet rats, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.800 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). Verify against current literature before clinical use.
Inhibits carbonic anhydrase II in the ciliary body, reducing aqueous humor production and lowering intraocular pressure.
Stinging on application. May be used alone or with timolol (Cosopt). Primary treatment for glaucoma in dogs. Less effective in cats and horses. Apply q8-12h.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Pet Rat drugs
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A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | 1 drop/eye | q8h | Strong | Gelatt KN, MacKay EO. Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet Ophthalmol. 2001;4:61-67. doi:10.1046/j.1463-5224.2001.00141.x; Cawrse MA, Ward DA, Hendrix DV. Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Am J Vet Res. 2001;62:859-863. doi:10.2460/ajvr.2001.62.859 — Plumb's 10th ed printed p.1362, Dorzolamide Ophthalmic monograph. |
| Cat (Domestic) | TOPICAL | 1 drop/eye | q8-12h | Weak |
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