ExoticRx · exoticrx.com/drugs/dorzolamide-timolol-ophthalmic
US brand names:Cosopt
Dorzolamide inhibits carbonic anhydrase in ciliary body, reducing aqueous humor production. Timolol is a beta-blocker reducing aqueous production via different mechanism. Additive IOP-lowering.
Contraindicated with systemic beta-blockers (additive bradycardia). Avoid in cats with asthma. Local stinging common. Monitor IOP response.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL (ophthalmic) | Additive IOP-lowering effect | q8-12h | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1389 (2026-08-01). |
| Cat (Domestic) | TOPICAL (ophthalmic) | Timolol component — avoid in cats with asthma | q8-12h | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1389 (2026-08-01). |
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