Which species have cited Ethanol (Antidotal) dosing data?

Ethanol (Antidotal) dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Ethanol (Antidotal) a controlled substance?

Ethanol (Antidotal) is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What is the constant rate infusion (CRI) dose for Ethanol (Antidotal)?

Ethanol (Antidotal) has 2 CRI dose rules in the ExoticRx formulary, covering Dog (Domestic), Cat (Domestic). See the CRI section on this page for routes, dose ranges, and source citations.

Ethanol (Antidotal)

US brand names:Ethanol Injection USP

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Ethanol (Antidotal) is dosed at 600 mg/kg IV Loading 600mg/kg IV then CRI in dogs, per Shell L. Ethylene Glycol Toxicity. Veterinary Information Network; https://www.vin.com/vin_ce/abvp/html/ethylene_glycol_toxicity.html. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).. Verify against current literature before clinical use.

Drug Class

Antidote

Routes

Indications

Ethylene glycol toxicosisEthylene glycol toxicosis (when fomepizole unavailable)

Mechanism of Action

Competitive substrate for alcohol dehydrogenase with higher affinity than ethylene glycol or methanol, preventing formation of toxic metabolites.

Side effects & warnings

Fomepizole preferred when available. Causes significant CNS depression and hypoglycemia. Requires constant rate infusion and close monitoring. ICU setting only.

Species with Ethanol (Antidotal) dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugs All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Shell L. Ethylene Glycol Toxicity. Veterinary Information Network; https://www.vin.com/vin_ce/abvp/html/ethylene_glycol_toxicity.html. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).
· Thrall M, Connally H, Grauer G, Hamar D. Ch 47: Ehtylene glycol. In: Peterson M, Talcott P, eds. Small Animal Toxicology. 3rd ed. Elsevier; 2013:551-567. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).

Constant rate infusion (CRI)

Ethanol (Antidotal) CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.

Species	Route	Rate	Indication	Evidence	Source
Dog (Domestic)	IV	600 mg/kgLoading 600mg/kg IV then CRI	Ethylene glycol toxicosis (when fomepizole unavailable)	Moderate	Shell L. Ethylene Glycol Toxicity. Veterinary Information Network; https://www.vin.com/vin_ce/abvp/html/ethylene_glycol_toxicity.html. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).
Cat (Domestic)	IV	600 mg/kgLoading dose then CRI q6h for 48h	Ethylene glycol toxicosis	Moderate	Thrall M, Connally H, Grauer G, Hamar D. Ch 47: Ehtylene glycol. In: Peterson M, Talcott P, eds. Small Animal Toxicology. 3rd ed. Elsevier; 2013:551-567. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	600 mg/kg	Loading 600mg/kg IV then CRI	Moderate	Shell L. Ethylene Glycol Toxicity. Veterinary Information Network; https://www.vin.com/vin_ce/abvp/html/ethylene_glycol_toxicity.html. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).
Cat (Domestic)	IV	600 mg/kg	Loading dose then CRI q6h for 48h	Moderate	Thrall M, Connally H, Grauer G, Hamar D. Ch 47: Ehtylene glycol. In: Peterson M, Talcott P, eds. Small Animal Toxicology. 3rd ed. Elsevier; 2013:551-567. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).

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View Plans

Dog (Domestic)IV
600 mg/kgLoading 600mg/kg IV then CRI
Ethylene glycol toxicosis (when fomepizole unavailable)
ModerateShell L. Ethylene Glycol Toxicity. Veterinary Information Network; https://www.vin.com/vin_ce/abvp/html/ethylene_glycol_toxicity.html. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).
Cat (Domestic)IV
600 mg/kgLoading dose then CRI q6h for 48h
Ethylene glycol toxicosis
ModerateThrall M, Connally H, Grauer G, Hamar D. Ch 47: Ehtylene glycol. In: Peterson M, Talcott P, eds. Small Animal Toxicology. 3rd ed. Elsevier; 2013:551-567. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.515 (2026-08-01).