What is Leuprolide used for?

Leuprolide is indicated for: Chronic egg-laying, Inhibition of ovulation, Ovarian adenocarcinoma, Ovarian neoplasia, reproductive behaviors, reproductive disorders, Reproductive suppression: chronic egg laying, Reproductive/hormonal suppression, Sexual, sexually related feather-damaging behavior (GnRH agonist).

Which species have cited Leuprolide dosing data?

Leuprolide dosing in the ExoticRx formulary covers 4 species: African Grey Parrot, Amazon Parrot, Blue-and-Gold Macaw, Cockatiel.

Is Leuprolide a controlled substance?

Leuprolide is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the warnings or contraindications for Leuprolide?

Initial hormone flare before suppression. Used for chronic egg-laying in birds and ferret adrenal disease. Cost may be prohibitive. Store depot formulations properly.

What are the side effects of Leuprolide?

Reported side effects, adverse reactions, and contraindications for Leuprolide: Initial hormone flare before suppression. Used for chronic egg-laying in birds and ferret adrenal disease. Cost may be prohibitive. Store depot formulations properly.

How does Leuprolide work?

GnRH agonist that initially stimulates then suppresses gonadotropin release through pituitary desensitization, reducing sex hormone production.

Leuprolide

US brand names:Lupron, Lupron Depot

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Leuprolide is dosed at 0.375–0.8 mg/kg IM q14d in african grey parrots, per Hawkins MG, Barron H, Speer BL, et al. Birds. In: Carpenter JW, eds. Exotic Animal Formulary, 4th ed., Elsevier Saunders, St. Louis, MO; 2013:183-437. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.462 (2026-08-01). — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Current Therapy in Avian Medicine and Surgery — ISBN 9781455746712, https://openlibrary.org/isbn/9781455746712. Verify against current literature before clinical use.

Drug Class

Endocrine

Routes

Indications

Backed by 5 published sources

· 42. Bailey TA, Apo MM. Pharmaceutics commonly used in avian medicine. In: Samour J, eds. Avian Medicine, 2nd ed., Mosby Elsevier, Edinburgh, Scotland; 2008:485-509. ; 606. Millam JR, Finney HL. Leuprolide acetate can reversibly prevent egg laying in cockatiels (Nymphicus hollandicus). Zoo Biol. 1994;13:149-155. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.462 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.7 (Hormones and Steroids Used in Birds). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Avian Medicine (Samour) — ISBN 9780723438328, https://openlibrary.org/isbn/9780723438328
· 471. Keller KA, Beaufrère H, Brandão J, et al. Long-term management of ovarian neoplasia in two cockatiels (Nymphicus hollandicus). J Avian Med Surg. 2013;27:44-52. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.483 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.13 (Oncologic Agents and Radiation Therapy Used in Birds). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929,

· 484. Klaphake E, Fecteau K, DeWit M, et al. Effects of leuprolide acetate on selected blood and fecal sex hormones in Hispaniolan Amazon parrots (Amazona ventralis). J Avian Med Surg. 2009;23:253-262. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.462 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.7 (Hormones and Steroids Used in Birds). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Hawkins MG, Barron H, Speer BL, et al. Birds. In: Carpenter JW, eds. Exotic Animal Formulary, 4th ed., Elsevier Saunders, St. Louis, MO; 2013:183-437. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.462 (2026-08-01). — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Current Therapy in Avian Medicine and Surgery — ISBN 9781455746712, https://openlibrary.org/isbn/9781455746712

· Martin KM. Psittacine behavioral pharmacotherapy. In: Leuscher AU, eds. Manual of Parrot Behavior; Blackwell Publishing, Ames, IA; 2006:267-280. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.473 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.10 (Psychotropic and Antiepileptic Agents Used in Birds.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

Leuprolide

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Leuprolide dosing data (7 dose rules)

Evidence levels across 7 dose rules

Backed by 5 published sources

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Leuprolide

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Leuprolide dosing data (7 dose rules)

Evidence levels across 7 dose rules

Backed by 5 published sources

Upgrade for Full Details

Articles mentioning Leuprolide

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