Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Levamisole is dosed at 8 mg/kg PO single dose in cattle, per LEVAMED SOLUBLE DRENCH POWDER - Levamisole Hydrochloride Powder [US Product Label for Cattle and Sheep]. Bimeda, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a5cd77e0-af84-4ef6-b0bf-b3dc706352c3 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.771 (2026-08-01). — Plumb's 10th ed (held) printed p.744, Levamisole monograph spanning p.743-745; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 520.1242a (Levamisole powder), conditions of use for Cattle: 8-8 mg/kg. Related tolerances: 21 CFR § 556.350. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-520.1242a — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Levamisole is used in cattle for GI nematodes, lungworms. Routes documented in cattle: PO. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 1 cited dose rule for Levamisole in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Levasole, Tramisol
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 8 mg/kg | single dose | GI nematodes, lungworms | Strong | LEVAMED SOLUBLE DRENCH POWDER - Levamisole Hydrochloride Powder [US Product Label for Cattle and Sheep]. Bimeda, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a5cd77e0-af84-4ef6-b0bf-b3dc706352c3 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.771 (2026-08-01). — Plumb's 10th ed (held) printed p.744, Levamisole monograph spanning p.743-745; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 520.1242a (Levamisole powder), conditions of use for Cattle: 8-8 mg/kg. Related tolerances: 21 CFR § 556.350. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-520.1242a — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 8 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.470 | • 8 mg/kg once PO, or approximately one 2.19-g bolus per 450-750 pounds |
| 8 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.470 | • Levamisole injection (for cattle): 8 mg/kg SQ into midneck area once, or approx- |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your cattle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Nicotinic acetylcholine receptor agonist causing sustained muscle contraction and paralysis in nematodes. Also has immunostimulant properties.
Narrow safety margin — toxicity causes cholinergic signs (salivation, tremors, dyspnea). TOXIC to dogs at high doses. Immunomodulatory use at low doses.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Levamisole dose range in cattle, with cited source references: PO 8 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Levamisole in cattle: PO.
Levamisole is indicated in cattle for: GI nematodes, lungworms.
These are general warnings for Levamisole across species; consult the cattle dosing table above for species-specific guidance. Narrow safety margin — toxicity causes cholinergic signs (salivation, tremors, dyspnea). TOXIC to dogs at high doses. Immunomodulatory use at low doses.
Why a species-specific page? Levamisole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.