Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Levamisole is dosed at 2–5 mg/kg PO q48h in dogs, per Johnson KC, Mackin A. Canine immune-mediated polyarthritis: part 2: diagnosis and treatment. J Am Anim Hosp Assoc. 2012;48(2):71-82. PMID: 22267168 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.771 (2026-08-01). — Plumb's 10th ed (held) printed p.744, Levamisole monograph spanning p.743-745; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — CEILING: Plumb's Veterinary Drug Handbook, Levamisole monograph, printed p.771 — "2 - 5 mg/kg (maximum of 150 mg/dog; NOT mg/kg) PO every 48 hours".. Levamisole is used in dogs for Adjunctive therapy for systemic lupus erythematosus (with prednisone; max 150 mg/dog per dose). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Levamisole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Levasole, Tramisol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–5 mg/kgmax 150 mg total | q48h | Variable | Adjunctive therapy for systemic lupus erythematosus (with prednisone; max 150 mg/dog per dose) | Weak | Johnson KC, Mackin A. Canine immune-mediated polyarthritis: part 2: diagnosis and treatment. J Am Anim Hosp Assoc. 2012;48(2):71-82. PMID: 22267168 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.771 (2026-08-01). — Plumb's 10th ed (held) printed p.744, Levamisole monograph spanning p.743-745; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — CEILING: Plumb's Veterinary Drug Handbook, Levamisole monograph, printed p.771 — "2 - 5 mg/kg (maximum of 150 mg/dog; NOT mg/kg) PO every 48 hours". |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5–8 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.470 | • Endoparasites: 5-8 mg/kg once PO (up to 10 mg/kg PO for 2 days). |
| 10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.470 | • Microfilaricide: 10 mg/kg q24h PO for 6-10 days (recommended to use |
| 10 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.470 | • Hookworms: 10 mg/kg/day for 2 days. |
| 0.5–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.470 | • Immunostimulant: 0.5-2 mg/kg 3 times/week PO. (In humans, the immunos- |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Nicotinic acetylcholine receptor agonist causing sustained muscle contraction and paralysis in nematodes. Also has immunostimulant properties.
Narrow safety margin — toxicity causes cholinergic signs (salivation, tremors, dyspnea). TOXIC to dogs at high doses. Immunomodulatory use at low doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Levamisole dose range in dogs, with cited source references: PO 2–5 mg/kg q48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Levamisole in dogs: PO.
Cited course lengths for Levamisole in dogs include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Levamisole is indicated in dogs for: Adjunctive therapy for systemic lupus erythematosus (with prednisone; max 150 mg/dog per dose).
These are general warnings for Levamisole across species; consult the dog dosing table above for species-specific guidance. Narrow safety margin — toxicity causes cholinergic signs (salivation, tremors, dyspnea). TOXIC to dogs at high doses. Immunomodulatory use at low doses.
Why a species-specific page? Levamisole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.