ExoticRx · exoticrx.com/drugs/linezolid
US brand names:Zyvox
Linezolid is dosed at 10–15 mg/kg PO q8-12h in dogs, per Foster JD, Trepanier LA, Ginn JA. Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog. J Am Anim Hosp Assoc. 2014;50(1):53-58. doi:10.5326/jaaha-ms-5947 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.791 (2026-08-01).. Verify against current literature before clinical use.
Binds 23S rRNA of the 50S ribosomal subunit, preventing formation of the 70S initiation complex. Active against MRSA and VRE.
Reserve for resistant infections. Thrombocytopenia with prolonged use (>14 days). Serotonin syndrome risk with concurrent serotonergic drugs. Expensive.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–15 mg/kg | q8-12h | Weak | Foster JD, Trepanier LA, Ginn JA. Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog. J Am Anim Hosp Assoc. 2014;50(1):53-58. doi:10.5326/jaaha-ms-5947 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.791 (2026-08-01). |
| Cat (Domestic) | PO | 10 mg/kg | q12h | Weak | Foster JD, Trepanier LA, Ginn JA. Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog. J Am Anim Hosp Assoc. 2014;50(1):53-58. doi:10.5326/jaaha-ms-5947 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.791 (2026-08-01). |
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