Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Linezolid is dosed at 10–15 mg/kg PO q8-12h in dogs, per Foster JD, Trepanier LA, Ginn JA. Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog. J Am Anim Hosp Assoc. 2014;50(1):53-58. doi:10.5326/jaaha-ms-5947 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.791 (2026-08-01).. Linezolid is used in dogs for MRSA/VRE infections. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Linezolid in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zyvox
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–15 mg/kg | q8-12h | 7-14 days | MRSA/VRE infections | Weak | Foster JD, Trepanier LA, Ginn JA. Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog. J Am Anim Hosp Assoc. 2014;50(1):53-58. doi:10.5326/jaaha-ms-5947 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.791 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds 23S rRNA of the 50S ribosomal subunit, preventing formation of the 70S initiation complex. Active against MRSA and VRE.
Reserve for resistant infections. Thrombocytopenia with prolonged use (>14 days). Serotonin syndrome risk with concurrent serotonergic drugs. Expensive.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Linezolid dose range in dogs, with cited source references: PO 10–15 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Linezolid in dogs: PO.
Cited course lengths for Linezolid in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Linezolid is indicated in dogs for: MRSA/VRE infections.
These are general warnings for Linezolid across species; consult the dog dosing table above for species-specific guidance. Reserve for resistant infections. Thrombocytopenia with prolonged use (>14 days). Serotonin syndrome risk with concurrent serotonergic drugs. Expensive.
Why a species-specific page? Linezolid pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.